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Fathers' immune system activation from infection, for instance, may have an impact on the behaviour of their offspring for at least two generations through the epigenetic regulation of reproductive cells (Tyebji, Hannan, & Tonkin, 2020)

however, recent studies have demonstrated its transient intracellular presence in pulmonary and immune cells, where defense against reactive oxygen species (ROS) is essential for its survival [3]

A small percentage of Hb is always auto-oxidized under normal physiological conditions resulting in the presence of metHb in blood, but metHb can also be present due to genetic abnormalities, exposure of red cells to certain drugs or toxins, or due to a deficit in antioxidants