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Irritation appears randomly and includes symptoms like redness, burning, or unusual dryness

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revealed that lactate can promote CD47-dependent immune evasion through histone lactylation reprogramming of GBM metabolism regulated by the heterochromatin component chromobox protein homolog 3 (CBX3), and additionally, histone lactylation can affect the immune microenvironment in GBM via interferon-regulated transcriptional programs ( Iron, as the core element of ferroptosis, is precisely regulated in the TME