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It is commonly used to treat conditions such as growth hormone deficiency, Turner syndrome, and Prader-Willi syndrome

Moreover, the abundance of GSH (110 mmol L 1 ) might favour the spontaneous reaction between GSH and FA, which, if not limited, could alter the GSH:GSSG ratio leading to oxidative stress

(Wei et al

It has also been reported that VEGF alters the expression and distribution of TJs proteins, leading to BBB hyperpermeability in hypoxia and autoimmune encephalomyelitis (Zhang et al., 2000)