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Additionally, the need for sterile equipment, trained personnel for administration, and continuous monitoring increases costs and protocol complexity, restricting use to hospital settings or specialized clinics [65]

AMPH Can Regulate Excitatory as Well as Catecholaminergic Signaling in LC Neurons We previously showed that regulation of the trafficking of a glutamate EAAT3 plays a critical role in regulating glutamatergic inputs into these cells

However, there is substantial debate about whether immobility truly reflects a depressive state or rather an adaptive coping strategy such as energy conservation [21, 22]

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