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A 2013 study linked low vitamin B12 and folate levels with an increased risk of age-related macular degeneration ( Although the reduction in risk cant be attributed to vitamin B12 only, it does suggest that getting enough may be important

Depending on the individual, they start working within 48 to 72 hours of the first dose, but they might take three months to completely correct a B12 deficiency

Subcutaneous administration of vitamin B12 is sometimes employed, especially in patients with congenital cobalamin metabolism disorders who require high doses to maintain normal metabolic pathways

Waiting more than 60 minutes extends the fasting period unnecessarily without additional bioavailability benefit