The interaction between AAT and the expression of endogenous antioxidant enzymes such as catalases and superoxide dismutase (SOD) has been known and studied for some time ( Recent studies have demonstrated that patients with PI ZZ genotype exhibit reduced expression of catalase and glutathione reductase, indicating an indirect role of alpha-1 antitrypsin (A1AT) in modulating reactive oxygen species (ROS) and reactive nitrogen species (RNS) levels
Brain Dev 30:3142 Goldsteins G, Hakosalo V, Jaronen M, Keuters MH, Lehtonen , Koistinaho J (2022) CNS Redox Homeostasis and Dysfunction in Neurodegenerative Diseases.Antioxidants (Basel)11 Asslih S, Damri O, Agam G (2021) Neuroinflammation as a Common Denominator of Complex Diseases (Cancer, Diabetes Type 2, and Neuropsychiatric Disorders).Int J Mol Sci22 Nezu J, Tamai I, Oku A, Ohashi R, Yabuuchi H, Hashimoto N, Nikaido H, Sai Y, Koizumi A, Shoji Y, Takada G, Matsuishi T, Yoshino M, Kato H, Ohura T, Tsujimoto G, Hayakawa J, Shimane M, Tsuji A (1999) Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter
Biomolecules 11:34
Soltaninejad and colleagues evaluated the effect of nebulized gentamycin (80 mg twice daily for 5 days) versus placebo on lung function given in patients with acute exacerbations of COPD
