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Tight junctions in the blood-brain barrier promote edema formation and infarct size in stroke - Ambivalent effects of sealing proteins

When the clinical condition is critical and the potential benefits outweigh the risks, cautious use of the above agents may be considered

The previously mentioned study finding 70% of GHK-Cu users showed increased collagen versus 50% for vitamin C and 40% for retinoic acid suggests copper peptides may represent the most effective topical collagen-building approach currently available

Although studies linking calcification and inflammation in PH are scarce, cytokines have been implicated in the regulation of calcification in the extra-pulmonary vasculature