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Loss of methylation of the ICR1 on the paternal allele results in the phenotype of Silver Russell syndrome (SRS) which may also arise from other genetic aberrations that have not yet been linked to the IGF-II production or signaling cascade including maternal uniparental dyssomnia of chromosome 7

Intermediate users commonly use 300-400 mcg daily, while advanced protocols may utilize 500 mcg daily or divided doses of 250 mcg twice per day

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