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Peptides derived from cytoskeletal proteins also tended to increase in abundance with age, including proteoforms of dematin actin-binding protein (DMTN), paralemmin-1 (PALM) and microtubule-associated proteins 1/2 (MAP1/2), which may represent degradation of full-length cytoskeletal proteins in later life, leading to cytoskeletal instability 36

J Biol Chem 290(5):27982811 Aman Y, Ryan B, Torsetnes SB, Knapskog A-B, Watne LO, McEwan WA, Fang EF (2020) Enhancing mitophagy as a therapeutic approach for neurodegenerative diseases