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According to the several studies conducted with different instrumental techniques, such as by Nuclear Magnetic Resonance ( 113 Cd-NMR [152]), X-ray diffraction, and molecular mechanics and dynamics calculations [153], metallated metallothioneins look like protein chains wrapped around a metal cluster, with multiple cysteines liganding metals through their thiolate groups [154], as exemplified in Scheme 13 for the tetra-metallated domain of a Cd-loaded MT

doi: 10.3390/ijms21124283 323 KimH-YJangH-JMuthamilSShinUCLyuJ-HKimS-Wet al

Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking

RyanMJDudashHJDochertyMGeronillaKBBakerBAHaffGGet al