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More DPCs (proliferation) that live longer (anti-apoptosis) generating stronger growth signals, combined with a reduced stop-growing signal (TGF-beta-1 reduction), creates conditions more favorable to sustained follicle activity

Metabolic studies Animals were given either 6 g/kg glucose or distilled water (2 mL/100 g body weight, n = 10 for all groups) by gavage every 6 h (at 06:20, 12:20, 18:20, and 24:20 h) for 38 days, defined as the long-term oscillating glucose (LOsG) or sham group

This issue is especially pronounced for lipid subclasses such as ceramides, which play a crucial role in driving insulin resistance via the Akt signaling pathway but are challenging to interpret due to their structural heterogeneity and inadequate mass spectrometric coverage (123)

Biomarkers of hepatic toxicity: an overview