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Only in patients with pre-existing conditions or improper dosing

The landmark STEP 1 trial, published in the New England Journal of Medicine in 2021, found that adults using semaglutide 2.4mg weekly alongside lifestyle support lost an average of 14.9% of body weight over 68 weeks, compared to 2.4% in the placebo group

Understanding vitamin B12's water solubility helps explain certain aspects of its metabolism, but deficiency risk is primarily related to inadequate dietary intake or malabsorption issues

Fibromyalgia patients with functional GI disorders should discuss this combination carefully with their provider before starting, as side effects may be more pronounced