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Read the evidence A 2017 meta-analysis (N = 1,211) found that in patients with hyperuricaemia and CKD, urate-lowering treatment slowed renal function decline, limited proteinuria and reduced the relative risk of cardiovascular events or renal failure by over 50% 12 A 2020 meta-analysis (N = 6,458) found that urate-lowering treatment did not significantly reduce the risk of major adverse cardiovascular events, kidney failure or all-cause mortality

168,169 Lactate-derived lactylation, found throughout the brain, influences chromatin state and gene expression (Fig