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Thus, it impairs Ca 2+ efflux through L-type calcium channels, resulting in a reduction in efflux Ca 2+ and an increase in intracellular Ca 2+ , which affects the systolic and diastolic functions of cardiac myocytes (44)

High levels of NO, in conjunction with ROS, can lead to the formation of peroxynitrite, a potent oxidant that can induce lipid peroxidation, DNA damage, and protein modification 56

The composite is injected subcutaneously into the tumor region before surgery, and after near-infrared (NIR) activation, the nanorobots self-propel into the deep tumor, releasing thrombin on demand to embolize the tumors blood supply

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