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In some cases, the affinity optimization is aimed at increasing the affinity by at least 2-fold, at least 3-fold, at least 4-fold, at least 5-fold, at least 6-fold, at least 7-fold, at least 8-fold, at least 9-fold, at least 10-fold, at least 20-fold, at least 30-fold, at least 40-fold, at least 50-fold, at least 100-fold, at least 500-fold, or at least 1,000-fold or more as compared to the affinity of the original antibody

This is one analysis's framing rather than settled industry consensus, but it's directionally consistent with separate reporting on site burden

Pegylated arginine deiminase (ADI-PEG-20), which duplicates arginine and increases tumor stress and cytotoxicity, increased the number of tumor-infiltrating T cells in phase I studies and was safe in combination with anti-PD-1 antibody, but with an increased risk of neutropenia

Potential role of vitamin D in the elderly to resist COVID-19 and to slow progression of Parkinsons disease