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However, for long-term storage (months or years), you should store the lyophilized vials in a freezer, ideally below -20C

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Whats more, the NOD-like receptor family pyrin domain-containing 3 (NLRP3), also upregulated by the activation of NF-B, 38 forms inflammasome and activates protein kinase C epsilon (PKC), 39 thus imparting IRS-1 40 (Fig