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Resident memory CD8+ T cells in regional lymph nodes mediate immunity to metastatic melanoma

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Studies with human CYP enzymes determined that several can metabolise APAP to NAPQI, the most important of which are CYP1A2, CYP2E1 and CYP3A4.15,16 These studies were later extended17 to demonstrate that, at high concentrations of APAP, metabolism via CYP2E1 predominates