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Furthermore, we recognize our mouse model is different from the previously studied AKITA mouse model ( M

Fetal bovine serum (FBS) was purchased from VivaCell (Shanghai, China)

The gut microbiota produces its own antigens through protein post-translational modifications, activates Toll-like receptor 4 induced by lipopolysaccharide (LPS), induces T helper cell translocation from type 1 (Th1) to type 2 (Th2), reduces the integrity of intercellular connections, and promotes AITD development through intestinal leakage (Lerner et al., 2017)

Beyond CRC, emerging evidence suggests that YYFZBJS and its constituent botanical drugs may also be beneficial in other cancer types ( Zhan et al., 2012)