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In vivo , chronic treatment with opioids promotes decrease (down-regulation), no change or increase (up-regulation) of OR (Bernstein and Welch, 2001

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Other than this, we observed no alterations in serum glucose, total protein, albumin, globulin, or albumin: globulin ratio across groups, suggesting that Se level in CON_HS was adequate for maintaining these attributes during HS, as also reported by Kumar et al

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demonstrated that Tom20 or Bax knockout effectively blocks ROS-induced pyroptosis, while antioxidant treatment significantly reduces Tom20 oxidation, Bax mitochondrial recruitment, and GSDME cleavage, further confirming that ROS serves as the central regulator of this signaling pathway (47)

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Of these patients, the most common etiology was immune-mediated [161]

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