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Patients who have lost twelve or fifteen kilos in their first six months of semaglutide or tirzepatide and then watch the scale stop moving in month seven often conclude, reasonably but incorrectly, that the medication has stopped working

In the cohort with brain fog, there were changes in genes associated with vitamin A metabolism (for example, DGAT2 , DHRS9 ) and regulation of leukocyte homeostasis (for example, CXCL10 , IL6R ) (Extended Data Fig

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