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[21] also observed high GSH accumulation by a strain of Lc

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1 Introduction Heart failure (HF) is one of the most prevalent cardiovascular diseases worldwide and poses a significant threat to human health (Zannad, 2018)

rhizome) with a weight ratio of 4:3:1 which is now manufactured under modern scientific quality controls.23 ICKT is considered a choleretic and hepatoprotective agent with relevant effects on bile formation,24 hepatic oxidative stress, hepatic fibrogenesis and stellate cells apoptosis.23-26 In this study, we tested the hypothesis that ICKT is able to influence the cholestasis development in the LPS-challenged rat liver through its known choleretic activity