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GC67918 MPO-IN-1 GC36650 MPO-IN-28 MPO-IN-28 (Compound 28) is a myeloperoxidase (MPO) inhibitor with an IC50 of 44 nM

143 , 144 Rhabdomyolysis: the intense muscular activity that contributes to the production of heat also causes severe damage to the muscle tissue itself, including marked swelling and edema, loss of microscopic structural features of normal muscle, inflammatory cell infiltration, breakdown of the muscle cell membranes and leakage of the intracellular contents into the bloodstream, and finally necrosis

Funding The research was supported in part by Grants-in-Aid for Challenging Exploratory Research and Scientific Research (B) from the Japan Society for the Promotion of Science (JSPS KAKENHI Grant Numbers JP26660218, JP21H02347, and JP24K01911, respectively) and by grant funds from the Uehara Memorial Foundation and Ito Foundation (all to R

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