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1 They showed that the patient increased her urinary TMA by 67% after a 15 mg/kg oral dose of TMA, in contrast to excretion by three control patients

The cost-effectiveness of management strategies, defining age- and sex-specific criteria for OSA, evaluating routine preoperative screening for OSA, evaluating the involvement of a sleep medicine specialist in OSA diagnosis, evaluating clinical prediction rules, comparing treatments for patients who cannot tolerate positive airway pressure, evaluating strategies to improve treatment compliance, and assessing the relationship between the severity of sleep Apnoea and long-term clinical outcomes were the nine highest priority FRN topics (Patel et al., 2013)

Nat Rev Gastroenterol Hepatol 18(3):196208

A Mendel randomized study confirmed the causal relationship between TMAO and its precursors and blood pressure (Wang H