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Accumulation of -syn in the ER results in calcium leakage into the cytosol, which then acts on -syn in a feedback-like manner potentiating further aggregation (Volles and Lansbury, 2002

Based on the acid-base characterization of MANH, [MNAH] is practically equal to [MNAH TOT ] in the pH media where the electrode potentials were measured, thus equation (12) takes the simpler form: Therefore, the linear regression analysis of these data afforded the standard redox potential as the intercept