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Although this was an ingenious approach, allosterically affecting the conformation of double-stranded DNA to prevent the AR DBD from binding has limited clinical applicability

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doi:10.1016/s0387-7604(83)80029-1 12.Savy N, Brossier D, Brunel-Guitton C, Ducharme-Crevier L, Du P-T, Jouvet P