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In particular, TGF is a key player in the induction of immunological tolerance (158) and production can be influenced by several mechanisms of parasite infection, including host homeostasis, pathogen-triggered TGF production, and parasite mimicry (158)

Li et al observed that endothelial cell pyroptosis is the dominant form of cell death in the initial phases of DMED development [89], and suppressing NOD-like receptor thermal protein domain associated protein 3 expression can significantly reduce pyroptotic activity in diabetic penile tissue of rats, enhancing the vascular endothelial function [91]

Specific disruption of glutathione-defense system with activatable single molecule-assembled nanoprodrug for boosted photodynamic/chemotherapy eradication of drug-resistant tumors

5.7 Nanotechnology: precision control of the microbiota-metabolite axis to boost cancer immunotherapy Nanotechnology transforms cancer immunotherapy by resolving key limitations of microbial metabolite-based interventionspoor bioavailability, off-target toxicity, inconsistent microbiota crosstalkvia engineered carriers that enable targeted metabolite delivery, controlled release, and selective gut-tumor-microbiome modulation