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Preclinically, combining such AMPK agonists or mitochondrial enhancers (e.g., spermidine) with ICIs has synergistic effects on restoring T-cell function and inhibiting tumor growth [386,387,388]

Noting that estrogen, in premenopausal women, is mainly synthesized in the ovaries: In premenopausal women aromatase inhibitors induce elevation and gonadotropin synthesis

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Despite no report on the application of PROTAC via targeting HDAC isoform in the field of neuroscience until now, there are publications supporting that PROTAC can be employed to degrade other target protein for improvement of brain disease