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Under hypoxic conditions, hypoxia-inducible factor-1 alpha (HIF-1) fails to undergo ubiquitination and degradation, then undergoes nuclear translocation to bind to promoters on the vascular endothelial growth factor gene, finally increasing the expression of HIF-1 and VEGF in endometriotic lesions

Neurotoxicology 25 , 233242 (2004)

Furthermore, where the description of one or more embodiments uses the term comprising, those skilled in the art would understand that, in some specific instances, the embodiment or embodiments can be alternatively described using the language consisting essentially of and/or consisting of. As used herein, the term about refers to a 10% variation from the nominal value

Despite exciting and emerging strides in NAD + biology, there are a variety of outstanding questions that warrant future systematic exploitation to accelerate the translation of remarkable bench work to effective clinical application in humans