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In April 2026, a federal policy change altered the regulatory classification of 12 of these peptides, a move ECRI and ISMP caution was not accompanied by new clinical evidence and should not be interpreted as a safety endorsement

Figure 1: Multiple infected knots at the injection sites on the upper arm of a woman who received injections with Lipodissolve, a drug that is not FDA approved, and sought treatment at a dermatology clinic one week after the injections | Permission Credit Figure 2: Appearance of the knots after two months of antibiotic treatment | Permission Credit Risks from improper injection techniques In addition to the risks that come with using unapproved fat-dissolving injections, improper or unsafe injection practices by unlicensed personnel could increase the risk for scarring and skin infections and result in serious complications

Rakhra, V., Galappaththy, S

Immunology Today, 1997