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Greater standardisation and transparent reporting will be essential to improve reproducibility and translational value

In particular, the impact of sudden sedentarism caused by home confinement and travel restrictions on the population's physical, biochemical, and mentalemotional health and fitness can lead to measurable impairment occurring in just a few days, sufficient to induce neuromuscular dysfunction, insulin resistance, lowered aerobic capacity, increased respiratory exchange ratio and fat deposition, and cause low-grade systemic inflammation (29)

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Insulin also stimulates lipid synthesis and storage by activating the same pathway and downstream targets such as SREBPs, ACC, and FAS (208)