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Importantly, this correlation was specific to the adipose tissue, as similar analyses conducted in the liver or skeletal muscle did not yield any significant correlations ( Figure 4f and Extended Data Figure 7b )

An anti-MITF small interfering RNA conjugated to a skin-penetrating peptide in a cream formulation was also successfully used for the treatment of patients with melasma, with an almost complete restoration of skin color on facial lesions after 12 weeks [110], but these agents need optimized topical delivery systems [111]

Tesamorelin has been associated with visceral adipose tissue reduction and may create a more pronounced metabolic effect compared to sermorelin

(2024) 103:e37114