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In the primary healthcare setting, the most commonly seen causes of vitamin B12 deficiency are related to abnormalities of digestion (atrophic gastritis, achlorhydria or the consequences of gastrectomy) or absorption (autoimmune pernicious anaemia, chronic pancreatitis, Crohns disease, the effect of medications that alter the mucosa of the ileum, or the consequences of surgical resection), and, to a lesser extent, a lack of exogenous supply

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Similarly, EVs originating from Candida albicans exacerbate host damage by reducing ROS production by activating arginine and NO metabolic pathways to decrease bacterial death [193]

Retatrutide is an unlicensed investigational peptide in the UK with no MHRA or EMA marketing authorisation as of 2024