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Leonurine alleviates ferroptosis in cisplatin-induced acute kidney injury by activating the Nrf2 signalling pathway

Vales-Gomez M, Erskine RA, Deacon MP, Strominger JL, Reyburn HT

Yuan et al (171) reported that Keap1 mutations are relatively common in HNSCC, and that a mutation in or lack of Keap1 inhibits ferroptosis in HNSCC by increasing NAD(P)H quinone dehydrogenase 1 (NQO1) levels through NRF2 activation

Microglial ferroptosis can activate neurotoxic astrocytes through pro-inflammatory signaling, and ferroptosis-related genes such as ALOX5/15 are highly enriched in microglia, yet this study does not establish whether ferroptosis is upstream in the cascade involving mitochondrial complex IV defects, oxidative stress, and neuroinflammation