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10.1159/000446600 44 Le PrellC

Advances in understanding the role of P-gp in doxorubicin resistance: Molecular pathways, therapeutic strategies, and prospects

We previously showed that oral intake of long-term oscillating glucose (LOsG, 4 times/day for 38 days) can lead to -cells gaining metabolic memory in reactive oxygen species (ROS) stress, inhibition of insulin and SOD-2 expression, and the development of prediabetes with hypoinsulinemia and glucose intolerance [3]