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In a similar study, the pivotal role for the IGF-1 in insulin sensitivity has received further support from liver-specific IGF-1 KO mice which exhibited overt insulin resistance and hyperinsulinaemia that was reversed by the administration of IGF-1 [161]

Synergistic Vasoactive Co-treatments: Exploring potential interactions and outcomes when combining central-acting melanocortin agonists with peripheral phosphodiesterase-5 (PDE-5) inhibitors in non-clinical assay designs