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Aberrant methylation of DNA and proteins, which causes alterations in chromatin structure and gene expression, are a common feature of cancer cells

In fact, we think that the phenotypic rescue might occur through a metabolic route rather than a vascular route, because vB12 treatment began in juvenile mice, when the brain vascular network is fully formed

We are also grateful to PharmaNutra S.p.A, Pisa, Italy, for providing the Sucrosomial B12 used in this study