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Intriguingly, while VRK2 wild-type tumors were resistant to APR-017 monotherapy, combinatorial treatment with the VRK2 inhibitor IC261 restored their sensitivity to APR-017 (Fig

Toxicol Lett 2012

Adult stem cells, including NSCs, HSCs, MSCs, and ESCs, serve as progenitor cells for their respective tissues and organs, possessing the ability to differentiate into specialized functional cells [281]