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A long-term deficiency can cause permanent damage to your body, including insomnia, neurologic damage, erectile dysfunction, and difficulty with bowel and bladder control

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Finally, as an additional point to the above discussion, the influence of aging on cancer treatment, especially immunotherapy, is also examined, with a focus on aging-associated pathways and genes such as IGF-1/IGF-1R, MTOR, ATM, TP53, BCL2, NF-B and STAT3 signaling and their roles in shaping immunotherapeutic efficacy

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