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Oxidative stress, energy metabolism disorders, and inflammatory responses that occur during this process cause severe damage to myocardial cells

doi: 10.3389/fnins.2025.1515374 Received 22 October 2024 Accepted 03 February 2025 Published 20 February 2025 Volume 19 - 2025 Edited by Matilde Otero-Losada, National Scientific and Technical Research Council (CONICET), Argentina Reviewed by Michael Henderson, Van Andel Institute, United States Minyoung Oh, Asan Medical Center, Republic of Korea Lenora Higginbotham, Emory University, United States Updates Copyright 2025 Rosal, Martin and Strafella

3.3.1 Estrogen maintains mitochondrial health via the PGC-1 signaling axis, inhibiting ferroptosis One of the core mechanisms of estrogens protective effect on mitochondria is through the activation of peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1), a master regulator of mitochondrial biogenesis

Results: DDC mice had increased AST, ALT, bilirubin, bile acids, ductular reaction and macrophage infiltration and reduced hepatocyte mRNA expression of Abcb11, Abcg8, Nr0b2 (SHP), Nr5a2 and Abcc2 mRNA relative to chow fed mice