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Introduction Proteotoxic stress, mitochondrial dysfunction, and genomic instability lead to cellular hyperactivity and are closely associated with age-related degenerative diseases such as atherosclerosis, type 2 diabetes, osteoporosis, and Alzheimers disease ( Following damage to the genome and epigenome of cells, many senescence-related secretions are mainly transcribed through NF-B, secreting interleukins, growth factors, proteases, cytokines, matrix-degrading enzymes, and metalloproteinases into the extracellular space

Studies have shown that intermittent fasting has cardioprotective effects, enhances neurocognitive function, and improves gut microbiome diversity, which indicates that it offers benefits for the whole body

Chung can combine penile implant surgery with manual modeling, penile plication, or plaque excision for the maximum correction

A minimum of 25% of a given chromosome arm was required to be altered to be scored positively