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Description

They are often related to: Mast cell activation and histamine release Mechanical variables Concentration differences Individual biological variability Local pH effects (in certain compounds such as NAD+) In most cases, these reactions are mild, localized, and self-resolving

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NO itself is a source of cytotoxic molecules, and its deleterious effects are enhanced by its ability to concentrate locally around tumor cells and the tumor microenvironment

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Yamauchi T, Kamon J, Ito Y, et al

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Effect of dietary sugar intake on biomarkers of subclinical inflammation: a systematic review and meta-analysis of intervention studies

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