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A cancer patient can experience a variety of symptoms, not limited to cough, diarrhoea, fatigue, fever, loss of appetite, shortness of breath, nausea, weakness, and weight loss [280, 281]

In a prospective study, high urinary betaine excretion was also associated with increased risk of heart failure in 325 subjects without diabetes mellitus who had been hospitalized for acute coronary syndrome (50)

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The intrastromal procedure we describea laser-assisted or manual mid-stromal lamellar dissection to create an intrastromal pocket in the recipient corneawould not require extensive training and could be easier and faster for surgeons to implement, given that the procedure is suture-free