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Excitotoxicity occurs through over-stimulation of glutamate receptors, specifically NMDAR, while in the non-receptor-mediated pathway, high glutamate concentrations reduce cystine uptake by inhibiting the System Xc-, leading to intracellular glutathione depletion and resulting in ROS accumulation, which contributes to increased lipid peroxidation, mitochondrial damage, and ultimately ferroptosis

Chen E, Chen Z, Chen L, Hu X

On a montr quune hausse de cet acide amin augmentait le taux de glutathion

For patients taking tirzepatide, adherence to prescribed dosing, attention to nutrition despite reduced appetite, adequate hydration, and regular follow-up are more important than supplementation