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In normal cases, PINK1 is degraded by healthy mitochondria, but when mitochondria become dysfunctional or damaged, PINK1 accumulates on their outer membranes, recruiting Parkin to mark the defective organelles for autophagic degradation

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Damaged mitochondria are not removed in time and accumulate to form waste mitochondria, which release more ROS, accelerating muscle atrophy (44)

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