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Taken together, it seems that B12 supplementation would be effective for migraine attack alleviation

Gebicki JM, Nauser T, Domazou A, Steinmann D, Bounds PL, Koppenol WH: Reduction of protein radicals by GSH and ascorbate: potential biological significance

However, future work should assess the role of liver PSAT1 on liver insulin action during hyperinsulinemic-euglycemic clamps combined with isotope tracers