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Robert, 1979

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To examine menopause-related alterations in intestinal or hepatic CYP3A4 activity, several studies compared the pharmacokinetics of midazolam, erythromycin, and prednisolone clearance in pre- and postmenopausal women and found no significant differences in drug metabolism according to menopausal status (Harris et al

Taken together, there is no doubt that measurement of endothelial function provides substantial prognostic information about future cardiovascular events in atherosclerotic disease and hypertension, whereas its role in primary prevention and whether the introduction of novel methods to assess endothelial function will further increase its prognostic potential 52 remains to be established