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These data are in accordance with studies in humans showing that the number of inflammatory hotspots in visceral AT upon weight reduction was highly variable and predictive for weight maintenance 50

After numerous failures of the therapeutic strategies acting against A, and the different works that strongly associated tau alterations to AD, many researchers focused their attention also on therapeutic strategies to target tau (Panza et al., 2016) by acting on the block or prevention of tau phosphorylation, through the activity of specific kinases or phosphatases, as well as on either inhibiting its aggregation or promoting its clearance (Iqbal et al., 2014