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Querdasi et al., 2023)

In the model proposed by Lee, homocysteine is shunted away from the methionine synthesis pathway and toward the GSH synthesis pathway, creating a relative deficiency of methyl donors in order to keep up with increased demand for the glutathione needed for POP conjugation ( Fig 3 )

However, these biomarkers are not always reliable and can be influenced by various factors, such as age, behavioral factors (e.g., nutrition and lifestyle), and concomitant pathologies