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doi:10.1016/j.envint.2017.11.020 Landrigan PJ, Meinhardt TJ, Gordon J, Lipscomb JA, Burg JR, Mazzuckelli LF, et al

GPX2 is expressed mainly in the gastrointestinal tract and also has extracellular activity, suggesting a role in protecting the intestinal epithelium from oxidative stress

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1 Although toxic ingestions causing hepatic failure are usually in excess of 150 mg/kg, an increasing number of reports has arisen to suggest that lower doses of APAP may confer acute liver injury and liver failure