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The results showed that MOX, alone or with Cu 2+ , caused oxidative stress, and growth and locomotion impairments, which were closely associated with the dysregulation of stress-responsive, neuromuscular-related, and apoptosis-related genes

It has fast-acting antidepressant effects, and animal studies show that the effects on behavior last well beyond the half-life

VALOR was a phase III, randomized, double-blind, placebo-controlled study that has evaluated the efficacy, safety, tolerability, and pharmacodynamic effects of tofersen on ALS with a confirmed SOD1 mutation (NCT02623699)

The discussion is concluded by thanking the audience for their interest in science and for joining the conversation, with an invitation to explore more content and resources 4m10s